Recombinant human erythropoietin improves neurological outcomes in very preterm infants
نویسندگان
چکیده
منابع مشابه
Recombinant human erythropoietin improves neurological outcomes in very preterm infants
OBJECTIVE To evaluate the efficacy and safety of repeated low-dose human recombinant erythropoietin (rhEPO) in the improvement of neurological outcomes in very preterm infants. METHODS A total of 800 infants of ≤32-week gestational age who had been in an intensive care unit within 72 hours after birth were included in the trial between January 2009 and June 2013. Preterm infants were randomly...
متن کاملRECOMBINANT ERYTHROPOIETIN AND BLOOD TRANSFUSION IN VERY LOW BIRTH WEIGHT INFANTS
ABSTRACT Background: Very low birth weight infants ( <1500 g) frequently require blood transfusions because of repeated blood sampling accompanied by anemia of prematurity. Methods: In an attempt to identify the effect of human recombinant erythropoietin to decrease the requirement for blood transfusions, erythropoietin was administered to 24 pre term infants less than 1500 g prospectively fro...
متن کاملRecombinant erythropoietin and blood transfusion in selected preterm infants.
OBJECTIVES To comprehensively identify preterm infants likely to require blood transfusion and to investigate the effectiveness of recombinant erythropoietin in this high risk subgroup. DESIGN Double blind randomised controlled trial. SETTING Neonatal Intensive Care Unit, Middlemore Hospital, Auckland, New Zealand. PATIENTS Preterm infants < 33 weeks gestation and < 1700 g birth weight me...
متن کاملErythropoietin improves neurodevelopmental outcome of extremely preterm infants.
OBJECTIVE Erythropoietin has been reported to possess neuroprotective properties in animal studies. No previous studies have investigated the neurodevelopmental outcome of extremely low birth weight (ELBW) infants treated with recombinant human erythropoietin (rEpo) and evaluated it at school age. METHODS Of 200 ELBW infants treated from 1993 to 1998, 171 (86%) survived, and 148 (87%) were fo...
متن کاملEffects of early human recombinant erythropoietin therapy on the transfusion in healthy preterm infants.
OBJECTIVE Early recombinant erythropoietin therapy and iron therapy would decrease the need for red blood cells transfusions and prevents anemia of prematurity. METHODS Fifty-eight preterm infants in newborn services at Ghaem Medical Center randomly were assigned, among them 18 patients were excluded. A total of 40 preterm infants with gestational age 28-34 weeks, birth weight 1000-1750 g fol...
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ژورنال
عنوان ژورنال: Annals of Neurology
سال: 2016
ISSN: 0364-5134,1531-8249
DOI: 10.1002/ana.24677